Report of the workflow results

Author

Ellis Franklin

Published

2024-04-23

1 The results as an interactive table


2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile


Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 10 most sensitive clusters

Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 3: DR curves for the 1st cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000186757.1 chia.1 0.3 FALSE U
ENSDART00000050271.9 hexb 39.7 FALSE dec
ENSDART00000099847.5 st3gal7 2.8 FALSE dec
Figure 4: Table of the 1st cluster content


Cluster 43 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 5: DR curves for the 2nd cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000144335.2 cyp27c1 7.3 FALSE inc
ENSDART00000018676.7 cyp3c1 42.0 FALSE inc
ENSDART00000130130.4 cyp3c3 1.2 FALSE U
ENSDART00000054228.6 lrata 37.8 FALSE inc
ENSDART00000152432.2 lratb.2 1.9 FALSE inc
ENSDART00000127075.3 ugt1b1 3.8 FALSE dec
ENSDART00000124017.3 ugt2a7 2.5 FALSE dec
ENSDART00000162089.2 ugt2a7 1.7 FALSE dec
ENSDART00000105604.5 zgc:77938 2.9 FALSE dec
Figure 6: Table of the 2nd cluster content


Cluster 10 - 15 transcripts (~ 25% < 2.07 μg/L)

Driver GO terms : sphingolipid metabolic process

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 7: DR curves for the 3rd cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000146650.2 asah2 1.34 FALSE dec
ENSDART00000013343.8 b4galt6 38.51 FALSE dec
ENSDART00000025385.8 cers2a 25.77 FALSE dec
ENSDART00000172824.2 cers3a 1.74 FALSE dec
ENSDART00000011076.7 cers5 2.59 FALSE dec
ENSDART00000075567.6 enpp7.1 0.84 FALSE U
ENSDART00000150118.4 gba2 1.39 FALSE dec
ENSDART00000022621.11 kdsr 2.40 FALSE dec
ENSDART00000083898.7 plpp3 5.29 FALSE dec
ENSDART00000147420.2 sgpl1 2.57 FALSE dec
ENSDART00000172269.2 smpd3 49.35 FALSE dec
ENSDART00000164652.2 SPHK1 36.01 FALSE dec
ENSDART00000171454.2 sphk2 3.60 FALSE dec
ENSDART00000188829.1 st6galnac4 23.11 FALSE dec
ENSDART00000183528.1 ugt8 4.12 FALSE dec
Figure 8: Table of the 3rd cluster content


Cluster 37 - 5 transcripts (~ 25% < 2.19 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 9: DR curves for the 4th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000101304.5 atg12 31.1 FALSE inc
ENSDART00000041304.8 atg3 2.2 FALSE U
ENSDART00000113162.4 pi4kaa 42.3 FALSE dec
ENSDART00000101265.5 pik3c3 3.9 FALSE inc
ENSDART00000015694.7 rab5ab 1.7 FALSE dec
Figure 10: Table of the 4th cluster content


Cluster 86 - 3 transcripts (~ 25% < 2.34 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 11: DR curves for the 5th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000006099.9 lims2 4.6 FALSE inc
ENSDART00000064187.7 parvaa 2.1 FALSE dec
ENSDART00000011751.9 parvb 2.6 FALSE inc
Figure 12: Table of the 5th cluster content


Cluster 68 - 17 transcripts (~ 25% < 2.36 μg/L)

Driver GO terms :

KEGG pathways : Lysosome

Wikipathways :

Figure 13: DR curves for the 6th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000058339.7 ap3s2 3.4 FALSE inc
ENSDART00000189874.1 ap4s1 35.2 FALSE inc
ENSDART00000178932.2 cltb 2.8 FALSE dec
ENSDART00000062749.6 cts12 52.4 FALSE dec
ENSDART00000060245.4 ctsh 33.8 FALSE inc
ENSDART00000034102.7 ctss2.2 58.7 FALSE inc
ENSDART00000172292.2 gga3b 42.6 FALSE dec
ENSDART00000121714.5 gnptab 2.3 FALSE U
ENSDART00000141771.2 gnptg 37.4 FALSE inc
ENSDART00000139087.3 lgmn 1.5 FALSE U
ENSDART00000157619.2 litaf 43.3 TRUE inc
ENSDART00000146101.2 mcoln1a 2.8 FALSE dec
ENSDART00000126129.3 nagpa 1.9 FALSE dec
ENSDART00000163398.2 pla2g15 2.4 FALSE dec
ENSDART00000058491.7 ppt1 45.4 FALSE inc
ENSDART00000158192.2 ppt2 2.2 FALSE bell
ENSDART00000142922.2 slc17a5 3.5 FALSE dec
Figure 14: Table of the 6th cluster content


Cluster 17 - 28 transcripts (~ 25% < 2.55 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 15: DR curves for the 7th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000130801.3 acsl1b 2.18 FALSE dec
ENSDART00000101126.5 alox12 3.38 FALSE dec
ENSDART00000011076.7 cers5 2.59 FALSE dec
ENSDART00000140882.2 crppa 18.97 FALSE inc
ENSDART00000043156.6 cyp17a1 2.73 FALSE dec
ENSDART00000172882.2 cyp27b1 3.01 FALSE dec
ENSDART00000190178.1 dhcr7 2.41 FALSE dec
ENSDART00000179784.1 ERG28 41.26 FALSE dec
ENSDART00000121859.3 fa2h 1.67 FALSE dec
ENSDART00000166508.2 fdft1 1.49 FALSE dec
ENSDART00000078972.5 fitm1l 27.73 FALSE inc
ENSDART00000153390.2 gpam 30.83 FALSE dec
ENSDART00000159216.2 hmgcs1 2.98 FALSE dec
ENSDART00000080925.4 impad1 2.66 FALSE dec
ENSDART00000181004.1 insig2 36.86 FALSE dec
ENSDART00000087241.6 lss 0.49 FALSE U
ENSDART00000034054.8 nus1 28.81 FALSE dec
ENSDART00000144484.2 PYURF 7.37 FALSE inc
ENSDART00000065600.5 sc5d 2.28 FALSE dec
ENSDART00000141130.2 scap 37.09 FALSE dec
ENSDART00000046802.7 sccpdha.1 1.98 FALSE dec
ENSDART00000149351.2 scd 23.97 FALSE inc
ENSDART00000135606.3 si:dkey-205h13.1 3.42 FALSE inc
ENSDART00000079879.5 si:dkey-91i10.3 3.26 FALSE dec
ENSDART00000188829.1 st6galnac4 23.11 FALSE dec
ENSDART00000163477.3 tamm41 34.60 FALSE inc
ENSDART00000183528.1 ugt8 4.12 FALSE dec
ENSDART00000005923.7 zgc:77375 34.02 FALSE dec
Figure 16: Table of the 7th cluster content


Cluster 73 - 14 transcripts (~ 25% < 2.96 μg/L)

Driver GO terms : fatty acid transport

KEGG pathways : PPAR signaling pathway

Wikipathways : PPAR signaling pathway

Figure 17: DR curves for the 8th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000056745.6 acox3 3.06 FALSE dec
ENSDART00000130801.3 acsl1b 2.18 FALSE dec
ENSDART00000088168.6 CABZ01055347.1 26.93 FALSE dec
ENSDART00000050753.6 cd36 0.38 FALSE U
ENSDART00000145375.5 cpt1aa 2.96 FALSE dec
ENSDART00000153935.2 cyp8b2 2.21 FALSE dec
ENSDART00000033724.7 fabp3 38.40 FALSE inc
ENSDART00000026180.9 fabp7a 3.60 FALSE inc
ENSDART00000041229.5 fabp7b 39.95 FALSE inc
ENSDART00000101918.5 proca1 3.66 FALSE inc
ENSDART00000103491.5 rbp7b 17.67 FALSE inc
ENSDART00000149351.2 scd 23.97 FALSE inc
ENSDART00000079879.5 si:dkey-91i10.3 3.26 FALSE dec
ENSDART00000170147.2 slc27a4 2.98 FALSE dec
Figure 18: Table of the 8th cluster content


Cluster 76 - 36 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : intracellular protein transport

KEGG pathways :

Wikipathways :

Figure 19: DR curves for the 9th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000140042.2 ap1b1 35.91 FALSE dec
ENSDART00000170714.3 ap1g1 43.08 FALSE dec
ENSDART00000135761.3 ap1s2 49.21 FALSE inc
ENSDART00000046587.7 ap2m1a 32.77 FALSE inc
ENSDART00000139499.2 ap2m1a 2.24 FALSE dec
ENSDART00000058339.7 ap3s2 3.43 FALSE inc
ENSDART00000189874.1 ap4s1 35.23 FALSE inc
ENSDART00000002824.10 appbp2 40.08 FALSE dec
ENSDART00000144920.3 clta 2.25 FALSE dec
ENSDART00000178932.2 cltb 2.76 FALSE dec
ENSDART00000011201.7 copz1 32.50 FALSE inc
ENSDART00000023058.8 efhc1 4.30 FALSE bell
ENSDART00000123935.4 erbin 31.50 TRUE dec
ENSDART00000182827.1 gga1 51.01 FALSE dec
ENSDART00000172292.2 gga3b 42.59 FALSE dec
ENSDART00000142080.2 kpna1 2.82 FALSE bell
ENSDART00000074519.4 kpna3 2.48 FALSE dec
ENSDART00000066123.7 kpna6 36.86 FALSE dec
ENSDART00000187730.1 LO017722.1 28.03 FALSE dec
ENSDART00000110839.4 mon1a 2.03 FALSE dec
ENSDART00000124582.3 napbb 36.34 FALSE dec
ENSDART00000060853.5 pex10 0.63 FALSE U
ENSDART00000183661.1 pex14 3.77 TRUE dec
ENSDART00000060766.4 rab11a 4.30 FALSE dec
ENSDART00000055810.8 rab1ba 22.42 FALSE dec
ENSDART00000034124.8 rab5aa 36.94 FALSE dec
ENSDART00000100173.6 ranbp3b 29.35 FALSE dec
ENSDART00000177459.2 RIC1 31.81 FALSE dec
ENSDART00000084598.6 selenos 3.23 FALSE U
ENSDART00000144925.3 snx27a 26.89 FALSE dec
ENSDART00000146275.3 strada 2.09 FALSE inc
ENSDART00000191347.1 STRADB 48.37 FALSE dec
ENSDART00000087797.5 tgfbrap1 23.45 FALSE dec
ENSDART00000037183.6 tmed2 1.76 FALSE dec
ENSDART00000067621.6 vps37c 32.36 FALSE dec
ENSDART00000187421.1 zgc:77650 3.04 FALSE inc
Figure 20: Table of the 9th cluster content


Cluster 42 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 21: DR curves for the 10th cluster
id external_gene_name BMD.zSD TF trend
ENSDART00000021009.9 cbfa2t3 2.5 FALSE bell
ENSDART00000167759.2 ldb1b 31.6 TRUE dec
ENSDART00000044208.6 lmo1 3.2 TRUE inc
ENSDART00000020529.9 tcf3a 35.7 TRUE dec
Figure 22: Table of the 10th cluster content