Report of the workflow results

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile

Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 10 most sensitive clusters

Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 3: DR curves for the 1st cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000186757.1	chia.1	0.3	FALSE	U
ENSDART00000050271.9	hexb	39.7	FALSE	dec
ENSDART00000099847.5	st3gal7	2.8	FALSE	dec

Figure 4: Table of the 1st cluster content

Cluster 43 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 5: DR curves for the 2nd cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000144335.2	cyp27c1	7.3	FALSE	inc
ENSDART00000018676.7	cyp3c1	42.0	FALSE	inc
ENSDART00000130130.4	cyp3c3	1.2	FALSE	U
ENSDART00000054228.6	lrata	37.8	FALSE	inc
ENSDART00000152432.2	lratb.2	1.9	FALSE	inc
ENSDART00000127075.3	ugt1b1	3.8	FALSE	dec
ENSDART00000124017.3	ugt2a7	2.5	FALSE	dec
ENSDART00000162089.2	ugt2a7	1.7	FALSE	dec
ENSDART00000105604.5	zgc:77938	2.9	FALSE	dec

Figure 6: Table of the 2nd cluster content

Cluster 10 - 15 transcripts (~ 25% < 2.07 μg/L)

Driver GO terms : sphingolipid metabolic process

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 7: DR curves for the 3rd cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000146650.2	asah2	1.34	FALSE	dec
ENSDART00000013343.8	b4galt6	38.51	FALSE	dec
ENSDART00000025385.8	cers2a	25.77	FALSE	dec
ENSDART00000172824.2	cers3a	1.74	FALSE	dec
ENSDART00000011076.7	cers5	2.59	FALSE	dec
ENSDART00000075567.6	enpp7.1	0.84	FALSE	U
ENSDART00000150118.4	gba2	1.39	FALSE	dec
ENSDART00000022621.11	kdsr	2.40	FALSE	dec
ENSDART00000083898.7	plpp3	5.29	FALSE	dec
ENSDART00000147420.2	sgpl1	2.57	FALSE	dec
ENSDART00000172269.2	smpd3	49.35	FALSE	dec
ENSDART00000164652.2	SPHK1	36.01	FALSE	dec
ENSDART00000171454.2	sphk2	3.60	FALSE	dec
ENSDART00000188829.1	st6galnac4	23.11	FALSE	dec
ENSDART00000183528.1	ugt8	4.12	FALSE	dec

Figure 8: Table of the 3rd cluster content

Cluster 37 - 5 transcripts (~ 25% < 2.19 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 9: DR curves for the 4th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000101304.5	atg12	31.1	FALSE	inc
ENSDART00000041304.8	atg3	2.2	FALSE	U
ENSDART00000113162.4	pi4kaa	42.3	FALSE	dec
ENSDART00000101265.5	pik3c3	3.9	FALSE	inc
ENSDART00000015694.7	rab5ab	1.7	FALSE	dec

Figure 10: Table of the 4th cluster content

Cluster 86 - 3 transcripts (~ 25% < 2.34 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 11: DR curves for the 5th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000006099.9	lims2	4.6	FALSE	inc
ENSDART00000064187.7	parvaa	2.1	FALSE	dec
ENSDART00000011751.9	parvb	2.6	FALSE	inc

Figure 12: Table of the 5th cluster content

Cluster 68 - 17 transcripts (~ 25% < 2.36 μg/L)

Driver GO terms :

KEGG pathways : Lysosome

Wikipathways :

Figure 13: DR curves for the 6th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000058339.7	ap3s2	3.4	FALSE	inc
ENSDART00000189874.1	ap4s1	35.2	FALSE	inc
ENSDART00000178932.2	cltb	2.8	FALSE	dec
ENSDART00000062749.6	cts12	52.4	FALSE	dec
ENSDART00000060245.4	ctsh	33.8	FALSE	inc
ENSDART00000034102.7	ctss2.2	58.7	FALSE	inc
ENSDART00000172292.2	gga3b	42.6	FALSE	dec
ENSDART00000121714.5	gnptab	2.3	FALSE	U
ENSDART00000141771.2	gnptg	37.4	FALSE	inc
ENSDART00000139087.3	lgmn	1.5	FALSE	U
ENSDART00000157619.2	litaf	43.3	TRUE	inc
ENSDART00000146101.2	mcoln1a	2.8	FALSE	dec
ENSDART00000126129.3	nagpa	1.9	FALSE	dec
ENSDART00000163398.2	pla2g15	2.4	FALSE	dec
ENSDART00000058491.7	ppt1	45.4	FALSE	inc
ENSDART00000158192.2	ppt2	2.2	FALSE	bell
ENSDART00000142922.2	slc17a5	3.5	FALSE	dec

Figure 14: Table of the 6th cluster content

Cluster 17 - 28 transcripts (~ 25% < 2.55 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 15: DR curves for the 7th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000130801.3	acsl1b	2.18	FALSE	dec
ENSDART00000101126.5	alox12	3.38	FALSE	dec
ENSDART00000011076.7	cers5	2.59	FALSE	dec
ENSDART00000140882.2	crppa	18.97	FALSE	inc
ENSDART00000043156.6	cyp17a1	2.73	FALSE	dec
ENSDART00000172882.2	cyp27b1	3.01	FALSE	dec
ENSDART00000190178.1	dhcr7	2.41	FALSE	dec
ENSDART00000179784.1	ERG28	41.26	FALSE	dec
ENSDART00000121859.3	fa2h	1.67	FALSE	dec
ENSDART00000166508.2	fdft1	1.49	FALSE	dec
ENSDART00000078972.5	fitm1l	27.73	FALSE	inc
ENSDART00000153390.2	gpam	30.83	FALSE	dec
ENSDART00000159216.2	hmgcs1	2.98	FALSE	dec
ENSDART00000080925.4	impad1	2.66	FALSE	dec
ENSDART00000181004.1	insig2	36.86	FALSE	dec
ENSDART00000087241.6	lss	0.49	FALSE	U
ENSDART00000034054.8	nus1	28.81	FALSE	dec
ENSDART00000144484.2	PYURF	7.37	FALSE	inc
ENSDART00000065600.5	sc5d	2.28	FALSE	dec
ENSDART00000141130.2	scap	37.09	FALSE	dec
ENSDART00000046802.7	sccpdha.1	1.98	FALSE	dec
ENSDART00000149351.2	scd	23.97	FALSE	inc
ENSDART00000135606.3	si:dkey-205h13.1	3.42	FALSE	inc
ENSDART00000079879.5	si:dkey-91i10.3	3.26	FALSE	dec
ENSDART00000188829.1	st6galnac4	23.11	FALSE	dec
ENSDART00000163477.3	tamm41	34.60	FALSE	inc
ENSDART00000183528.1	ugt8	4.12	FALSE	dec
ENSDART00000005923.7	zgc:77375	34.02	FALSE	dec

Figure 16: Table of the 7th cluster content

Cluster 73 - 14 transcripts (~ 25% < 2.96 μg/L)

Driver GO terms : fatty acid transport

KEGG pathways : PPAR signaling pathway

Wikipathways : PPAR signaling pathway

Figure 17: DR curves for the 8th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000056745.6	acox3	3.06	FALSE	dec
ENSDART00000130801.3	acsl1b	2.18	FALSE	dec
ENSDART00000088168.6	CABZ01055347.1	26.93	FALSE	dec
ENSDART00000050753.6	cd36	0.38	FALSE	U
ENSDART00000145375.5	cpt1aa	2.96	FALSE	dec
ENSDART00000153935.2	cyp8b2	2.21	FALSE	dec
ENSDART00000033724.7	fabp3	38.40	FALSE	inc
ENSDART00000026180.9	fabp7a	3.60	FALSE	inc
ENSDART00000041229.5	fabp7b	39.95	FALSE	inc
ENSDART00000101918.5	proca1	3.66	FALSE	inc
ENSDART00000103491.5	rbp7b	17.67	FALSE	inc
ENSDART00000149351.2	scd	23.97	FALSE	inc
ENSDART00000079879.5	si:dkey-91i10.3	3.26	FALSE	dec
ENSDART00000170147.2	slc27a4	2.98	FALSE	dec

Figure 18: Table of the 8th cluster content

Cluster 76 - 36 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : intracellular protein transport

KEGG pathways :

Wikipathways :

Figure 19: DR curves for the 9th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000140042.2	ap1b1	35.91	FALSE	dec
ENSDART00000170714.3	ap1g1	43.08	FALSE	dec
ENSDART00000135761.3	ap1s2	49.21	FALSE	inc
ENSDART00000046587.7	ap2m1a	32.77	FALSE	inc
ENSDART00000139499.2	ap2m1a	2.24	FALSE	dec
ENSDART00000058339.7	ap3s2	3.43	FALSE	inc
ENSDART00000189874.1	ap4s1	35.23	FALSE	inc
ENSDART00000002824.10	appbp2	40.08	FALSE	dec
ENSDART00000144920.3	clta	2.25	FALSE	dec
ENSDART00000178932.2	cltb	2.76	FALSE	dec
ENSDART00000011201.7	copz1	32.50	FALSE	inc
ENSDART00000023058.8	efhc1	4.30	FALSE	bell
ENSDART00000123935.4	erbin	31.50	TRUE	dec
ENSDART00000182827.1	gga1	51.01	FALSE	dec
ENSDART00000172292.2	gga3b	42.59	FALSE	dec
ENSDART00000142080.2	kpna1	2.82	FALSE	bell
ENSDART00000074519.4	kpna3	2.48	FALSE	dec
ENSDART00000066123.7	kpna6	36.86	FALSE	dec
ENSDART00000187730.1	LO017722.1	28.03	FALSE	dec
ENSDART00000110839.4	mon1a	2.03	FALSE	dec
ENSDART00000124582.3	napbb	36.34	FALSE	dec
ENSDART00000060853.5	pex10	0.63	FALSE	U
ENSDART00000183661.1	pex14	3.77	TRUE	dec
ENSDART00000060766.4	rab11a	4.30	FALSE	dec
ENSDART00000055810.8	rab1ba	22.42	FALSE	dec
ENSDART00000034124.8	rab5aa	36.94	FALSE	dec
ENSDART00000100173.6	ranbp3b	29.35	FALSE	dec
ENSDART00000177459.2	RIC1	31.81	FALSE	dec
ENSDART00000084598.6	selenos	3.23	FALSE	U
ENSDART00000144925.3	snx27a	26.89	FALSE	dec
ENSDART00000146275.3	strada	2.09	FALSE	inc
ENSDART00000191347.1	STRADB	48.37	FALSE	dec
ENSDART00000087797.5	tgfbrap1	23.45	FALSE	dec
ENSDART00000037183.6	tmed2	1.76	FALSE	dec
ENSDART00000067621.6	vps37c	32.36	FALSE	dec
ENSDART00000187421.1	zgc:77650	3.04	FALSE	inc

Figure 20: Table of the 9th cluster content

Cluster 42 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 21: DR curves for the 10th cluster

id	external_gene_name	BMD.zSD	TF	trend
ENSDART00000021009.9	cbfa2t3	2.5	FALSE	bell
ENSDART00000167759.2	ldb1b	31.6	TRUE	dec
ENSDART00000044208.6	lmo1	3.2	TRUE	inc
ENSDART00000020529.9	tcf3a	35.7	TRUE	dec

Figure 22: Table of the 10th cluster content